Tanay Pal

The evolution of C–H activation/functionalization strategy has been potentially expediting the synthesis of target molecules through new disconnections in retrosynthetic analysis. By far the toughest challenge in this area is to regioselectively functionalize a particular sp3 C‒H bond in alkanes. The minute reactivity differences of multitude of inert C‒H bonds and the fluxionality in aliphatic chains restricts the selective transformation at a core site within a complex molecule. Hence to incorporate functionality at a-sp3 carbon to a functional group relies on the traditional electrophilic addition or radical based reactions. As a part of the DM group, I have been focused on directing and without directing group assisted distal C(sp3)‒H bond functionalization.

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Parallelly,  along with the group I am focusing on the new emerging field of electrocatalysis. The advantages of this field in terms of green methodologies as well as large scale synthesis are immense. Basically, we are paying attention into the redox metal and electrasyn merging distal C-H bond functionalization. The developed methodology would be based on functional group tolerance, highly chemoselective, atom- and step-economical towards sustainable chemistry.